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April 27, 2005
Prions and Your Brain
"Prions enter brain cells and there convert the normal cell protein PrPC to the prion form of the protein, called PrPSC. When normal cell proteins transform into prions, amino acids that are folded tightly into alpha helical structures relax into looser beta sheets. More and more PrPC molecules transform into PrPSC molecules, until eventually prions completely clog the infected brain cells. The cells misfire, work poorly, or don't work at all. In mad cow disease, for example, with their brain cells running amuck, the mad cows wobble and stagger and appear fearful--their "madness" is craziness, not anger. Sheep and goats with the disease scrapie, which is like mad cow disease, become so uncomfortable and itchy that they frantically rub up against anything they can, finally scraping off--hence, the name of the disease--most of their wool and hair (2)."
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Posted on April 27, 2005 08:33 AM by mad co282.
Filed in Mental Health Update under mad cow disease.
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